serum anti-inflammatory cytokines for evaluation of inflammatory status in endometriosis
نویسندگان
چکیده
background: endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in the affected women; its pathogenesis is yet to be fully understood, with an altered immunity as a possible key factor. the present study aimed to investigate the serum anti-inflammatory cytokine profile in the patients with endometriosis compared with the healthy controls. materials and methods: one hundred and sixty women were included, divided into two study groups (group i — endometriosis; group 2 — healthy women). we evaluated the serum levels of interleukin-1 receptor antagonist (il-1ra), il-2, il-2r, il-4, il-10, il-13, and il-15 with the use of human multiplex cytokine panels. statistical analyses (normality distribution analysis, independent t -test, mann–whitney u-test) were performed using ibm spss software (version 22.0) and graphpad prism (version 5.00); receiver operating characteristic curve were used to demonstrate the diagnostic performance of the studied markers. results: the mean serum level of il-1ra, il-4, and il-10 were significantly higher in women with endometriosis compared to women free of disease from the control group (30.155, 138.459, and 1.489, respectively, compared to 14.109, 84.710, and 0.688, respectively; p < 0.001, p < 0.001, and p = 0.002, respectively.). no significant differences in the mean serum levels of il-2, il-13, and il-15 were observed between the studied groups and il-2r had a very low detection rate. conclusion: endometriosis is associated with elevated levels of anti-inflammatory cytokines, il-1ra, il-4, and il-10, markers that have a potential role as a prognostic factor for endometriosis.
منابع مشابه
Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis
THE AIM OF THE STUDY The aim of the study was to investigate the serum pro-inflammatory cytokine profile in patients with diagnosed endometriosis. MATERIAL AND METHODS The study included 160 women, who were divided in two study groups (Group I - endometriosis; Group 2 - healthy). We evaluated the serum levels of interleukin (IL)-1β, IL-5, IL-6, IL-7, and IL-12, and of tumour necrosis factor α...
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Anti-inflammatory cytokines.
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عنوان ژورنال:
journal of research in medical sciencesجلد ۲۰، شماره ۷، صفحات ۰-۰
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